Researchers identify new target, develop new drug for cancer therapies


Opening up a new pathway to fight cancer, researchers have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to target that enzyme resistant to treatment. Researchers were able to use this finding to develop a drug that successfully inhibits tumor growth of melanoma as well as pancreatic and colorectal cancer in mice.

Researchers closer to uncovering a new feature in heart failure


Each cell in the average human body contains 23 pairs of chromosomes, with four telomeres on each pair. Telomeres cover the end of the chromosome, protecting it from deterioration or fusion with adjacent chromosomes. While there is a length range for classifying a healthy telomere, researchers found, for the first time ever, that people with heart failure have shorter telomeres within the cells that make up the heart muscle (known as cardiomyocytes).

Shortened telomeres linked to dysfunction in Duchenne muscular dystrophy, researchers find


A discovery about muscular dystrophy disorders has been made that suggests new possibilities for treatment. Researchers found that stem cells in the muscles of muscular dystrophy patients may, at an early age, lose their ability to regenerate new muscle, due to shortened telomeres.

Researchers review the clinical potential of senolytic drugs on aging


Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals. Aging experts say that, if proven to be effective and safe in humans, these drugs could be ‘transformative’ by preventing or delaying chronic conditions as a group instead of one at a time.

Beta blockers have positive effect in pulmonary arterial hypertension, researchers find


A common heart disease medication, beta blockers, may help treat pulmonary arterial hypertension (PAH), a debilitating lung disease, researchers have found. Caused by high blood pressure in the pulmonary arteries, PAH is a progressive disease which usually leads to right-sided heart failure and death within five to seven years of diagnosis. Right-sided heart failure is the leading cause of death in PAH patients.

New Zealand researchers makes 'natural born killer' cell discovery


An unexpected role for a white blood cell called the Natural Killer (NK) cell — a critical cell for ridding the body of infection and cancer, has been discovered. The NK cell is a ‘vigilante’ killer — a white blood cell that destroys invaders and cancer cells through a process of ‘identity card’ checking. The researchers’ new work shows that violent vigilante NK cells act as helper cells to start up the immune response.