It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation and other ills.
A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings point to a potential target for protecting the kidney health of individuals with obesity.
Morbid obesity affects the liver: almost one-third of all adults suffer from chronic fatty liver disease, which can lead to infections and even trigger cancer. Researchers have now found a signaling pathway in cells that play an important role in the development of fatty liver disease.
Considering weight across the life course, the prevalence of obesity among adults in the US rises considerably, suggesting that the effects on population health may be even more pervasive than previously understood, according to a new study.
Research has demonstrated the potential of a protein to treat or prevent metabolic diseases including obesity and diabetes.
By fleshing out how one signaling receptor contributes to causing obesity through its activity in fatty tissue but not in muscle cells, scientists have zeroed in on an important new avenue of exploration for combating metabolic disease. More than one-third of American adults are considered to be obese, which dramatically increases their risk for developing type 2 diabetes, non-alcoholic fatty liver disease, high blood pressure, and multiple inflammatory conditions.
In mice that are given a high-fat diet, an increased production of the enzyme DPP4 by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance.
A team of researchers used fMRI to investigate neural responses to food cues in overweight compared with lean adolescents.
In a small study that scanned the brains of teenagers while exposing them to tempting ‘food cues,’ researchers report that reduced activity in the brain’s ‘self-regulation’ system may be an important early predictor of adult obesity.
Loneliness and social isolation may represent a greater public health hazard than obesity, and their impact has been growing and will continue to grow, according to research.