A piece of the puzzle: Eight autism-related mutations in one gene


Researchers discover a large number of clustered mutations in a single gene, TRIO, that disrupt the development of the brain’s connections and likely contribute to the development of autism-spectrum disorders. The scientists also find that a sister gene linked to schizophrenia, KALRN, is inactive in early brain development, but becomes active in adolescence.

Could mutations and inherited genes play a role in cerebral palsy?


Hemiplegic cerebral palsy hampers movement in one side of a person’s body. In the first genetic study of its kind to exclusively focus on those with hemiplegic cerebral palsy, a group of researchers has investigated the genetic differences and hereditary factors involved in this neurodevelopmental condition.

Genetic predisposition to breast cancer due to non-BRCA mutations in Ashkenazi Jewish women


Genetic mutations in BRCA1 and BRCA2 increase the risk of breast and ovarian cancer in Ashkenazi Jewish women. A new article pexamines the likelihood of carrying another cancer-predisposing mutation in BRCA1, BRCA2 or another breast cancer gene among women of Ashkenazi Jewish ancestry with breast cancer who do not carry one of the founder mutations.