Cell model of the brain provides new knowledge on developmental disease


By reprogramming skin cells into nerve cells, researchers are creating cell models of the human brain. In a new study, the researchers describe how cells from patients with the severe developmental disease lissencephaly differ from healthy cells. The method can provide vital new knowledge on difficult-to-study congenital diseases.

Scientists construct first predictive model of inflammatory bowel disease


An in-depth, multi-omics approach to characterizing the immune component of inflammatory bowel disease (IBD) has been revealed by researchers. These results provide new insights into the biologic networks involved in IBD with potential to identify new targets and eventually novel interventions for the treatment of patients living with IBD.

Infection model developed for tickborne flaviviruses


Scientists have filled a research gap by developing a laboratory model to study ticks that transmit flaviviruses, such as Powassan virus. Powassan virus was implicated in the death of a New York man earlier this year. The unusual model involves culturing organs taken from Ixodes scapularis ticks and then infecting those organ cultures with flaviviruses.

Model for lighter armor developed


Engineers are working on developing new light-weight ceramic materials that resist fracture. They are working to better understand exactly how these materials, which are suited for Soldier personal protection and Army systems, fracture, and how they can be further improved. They are focusing on failure through cracking; the material eventually disintegrates into a granular-like state through a process called comminution.

Small molecule inhibitor prevents or impedes tooth cavities in a preclinical model


Researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model. The inhibitor blocks the function of a key virulence enzyme in an oral bacterium, a molecular sabotage that is akin to throwing a monkey wrench into machinery to jam the gears.

Novel stem cell-derived model created of inflammatory neurological disorder


An international team of scientists, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). In doing so, the team was able to identify unusual and surprising underlying genetic mechanisms that drive AGS and test strategies to inhibit the condition using existing drugs.