By reprogramming skin cells into nerve cells, researchers are creating cell models of the human brain. In a new study, the researchers describe how cells from patients with the severe developmental disease lissencephaly differ from healthy cells. The method can provide vital new knowledge on difficult-to-study congenital diseases.
An in-depth, multi-omics approach to characterizing the immune component of inflammatory bowel disease (IBD) has been revealed by researchers. These results provide new insights into the biologic networks involved in IBD with potential to identify new targets and eventually novel interventions for the treatment of patients living with IBD.
Researchers have created the first patient-derived laboratory model of macular degeneration, the leading cause of vision loss in older adults. With the new model, the team has identified possible drug targets for the disease, which they hope will help lead to an effective treatment.
Scientists have developed a new virtual model of mouse lung function that illuminates the relative importance of different factors that contribute to lung changes accompanying chronic inflammation.
A type of mouse widely used to assess how the human immune system responds to transplanted stem cells does not reflect what is likely to occur in patients, according to a new study.
Scientists have filled a research gap by developing a laboratory model to study ticks that transmit flaviviruses, such as Powassan virus. Powassan virus was implicated in the death of a New York man earlier this year. The unusual model involves culturing organs taken from Ixodes scapularis ticks and then infecting those organ cultures with flaviviruses.
Engineers are working on developing new light-weight ceramic materials that resist fracture. They are working to better understand exactly how these materials, which are suited for Soldier personal protection and Army systems, fracture, and how they can be further improved. They are focusing on failure through cracking; the material eventually disintegrates into a granular-like state through a process called comminution.
Researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model. The inhibitor blocks the function of a key virulence enzyme in an oral bacterium, a molecular sabotage that is akin to throwing a monkey wrench into machinery to jam the gears.
An international team of scientists, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). In doing so, the team was able to identify unusual and surprising underlying genetic mechanisms that drive AGS and test strategies to inhibit the condition using existing drugs.
Incentives have been identified that could encourage journals to ‘open the black box of peer review’ for the sake of improving transparency, reproducibility and trust in published research.