Discovery helps improve accuracy of CRISPR-Cas9 gene editing


A detailed study of how domains within the Cas9 protein move when the molecule binds to DNA has allowed scientists to locate the protein that monitors the fidelity of binding between the Cas9 single-guide RNA and its DNA target. The researchers then tweaked this domain to boost specificity, creating the highest fidelity Cas9 protein to date.

Three policies to improve children's language development


Bilingual children from low-income homes are at greater risk of falling behind their peers in developing the appropriate language skills for their age group, leading to poorer academic achievement over time. A new article addresses how inequality impacts children’s language development and details policies that can intervene.

Using machine learning to improve patient care


Doctors are often deluged by signals from charts, test results, and other metrics to keep track of. It can be difficult to integrate and monitor all of these data for multiple patients while making real-time treatment decisions, especially when data is documented inconsistently across hospitals. Now researchers are exploring ways for computers to help doctors make better medical decisions.

Silk could improve sensitivity, flexibility of wearable body sensors


From smart socks to workout clothes that measure exertion, wearable body sensors are becoming the latest ‘must-have’ technology. Now scientists report they are on the cusp of using silk, one of the world’s most coveted fabrics, to develop a more sensitive and flexible generation of these multi-purpose devices that monitor a slew of body functions.

Noninvasive retinal imaging may improve early detection of Alzheimer's disease


Alzheimer’s disease (AD) represents the leading cause of dementia worldwide. Currently, challenges in making an early and definitive diagnosis of AD limit opportunities to intervene with disease-modifying therapies before substantial neurodegeneration occurs. Neurodegeneration in AD has been attributed to the accumulation of amyloid-beta proteins in the central nervous system, and amyloid-beta may be present up to 20 years prior to the onset of cognitive symptoms. Recently, noninvasive imaging techniques have been developed that can accurately detect and monitor amyloid-beta deposition in the retinas of rodent AD models. The use of similar techniques to assess amyloid-beta accumulation in human retinas may enable significant advances in early detection and treatment of AD.