Discovery helps improve accuracy of CRISPR-Cas9 gene editing


A detailed study of how domains within the Cas9 protein move when the molecule binds to DNA has allowed scientists to locate the protein that monitors the fidelity of binding between the Cas9 single-guide RNA and its DNA target. The researchers then tweaked this domain to boost specificity, creating the highest fidelity Cas9 protein to date.

Superfly flight simulator helps unravel navigation in the brain


Researchers have identified two independent pathways in the fly brain that are integrated to allow successful navigation during flight. The study combined a flight simulator designed for flies with imaging of active neurons to show that landmark locations are processed separately in the fly brain from self-motion.