A detailed study of how domains within the Cas9 protein move when the molecule binds to DNA has allowed scientists to locate the protein that monitors the fidelity of binding between the Cas9 single-guide RNA and its DNA target. The researchers then tweaked this domain to boost specificity, creating the highest fidelity Cas9 protein to date.
A new role has been identified for the major Alzheimer’s risk factor ApoE4, suggesting that targeting the protein may help treat the disease. Researchers show that ApoE4 exacerbates the brain damage caused by toxic tangles of a different Alzheimer’s-associated protein: tau. In the absence of ApoE, tau tangles did very little harm to brain cells.
Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development. This is the first time that genome editing has been used to study gene function in human embryos, which could help scientists to better understand the biology of our early development.
Researchers discover a large number of clustered mutations in a single gene, TRIO, that disrupt the development of the brain’s connections and likely contribute to the development of autism-spectrum disorders. The scientists also find that a sister gene linked to schizophrenia, KALRN, is inactive in early brain development, but becomes active in adolescence.
Scientific literature in recent years has focused extensively on one genetic risk factor for Alzheimer’s disease, the ApoE4 gene variant. A recent study raises flags that scientists should investigate another important player, the TOMM40 gene.
A team of scientists has demonstrated a groundbreaking new method of gene synthesis — a vital research tool with real-world applications in everything from growing transplantable organs to developing treatments for cancer.
Researchers have established a link between hypoxia, a condition that reduces the flow of oxygen to tissues, and HOTAIR, a noncoding RNA or molecule that has been implicated in several types of cancer.
Chemical changes in the eye that can lead to blindness have been identified by scientists, report investigators.
A combination of whole exome sequencing, machine learning, and network analysis, has identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders, according to a study.
A gene has been identified by researchers that is thought to be associated with the types of brain damage that can be caused by pre-term birth.