Opening up a new pathway to fight cancer, researchers have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to target that enzyme resistant to treatment. Researchers were able to use this finding to develop a drug that successfully inhibits tumor growth of melanoma as well as pancreatic and colorectal cancer in mice.
A new study has uncovered the mechanisms by which treatment-resistant melanoma become vulnerable to cessation of a class of drugs called MAP kinase (MAPK)-targeted inhibitors. By identifying these mechanisms, the scientists discovered that therapeutic benefits for patients could derive from a one-two punch of a drug holiday of MAPK inhibitors followed by a class of drugs called DNA repair inhibitors.
Scientists have discovered that a combination of artemisinin, which is a potent anti-malarial drug, and aminolaevulinic acid, which is a photosensitizer, could kill colorectal cancer cells and suppress tumor growth more effectively than administering artemisinin alone. This novel combination therapy could also have fewer side effects.
Painful side effects from cancer medicines could be tackled with a drug that eases the effects of jetlag, research suggests.
The coralberry could offer new hope for asthmatics: researchers have extracted a new kind of active pharmaceutical ingredient from its leaves to combat this widespread respiratory disease. In mice, it almost completely inhibits the characteristic contraction of the airways. The plant itself is not exotic: it can be found in any well-stocked garden center.
Researchers have been able to demonstrate that reactive polypept(o)ides constitute ideal building blocks to control morphology and function of carrier systems in a simple but precise manner.
Taxanes inhibit cell division and make cancer cells sensitive to radiation therapy. A current study has investigated the underlying mechanisms of this action – and which biomarkers may be useful for predicting the success of therapy.
The future of international drug control treaties is in doubt because of recent treaty-violating decisions to legalize cannabis use in Canada, the United States and Uruguay. A professor, whose 2014 review of 20 years of cannabis research made world headlines, thinks so. If decriminalization is the way of the future, he advocates a cautious approach to policy reform that would involve trialing and evaluating the effects of incrementally more liberal drug policies.
An existing drug may one day protect premenopausal women from life-altering infertility that commonly follows cancer treatments, according to a new study.
Drugs developed to treat heart and blood vessel problems could be used in combination with chemotherapy to treat an aggressive form of adult leukemia, new research reveals.