Immune-cell based therapies opening a new frontier for cancer treatment carry unique, potentially lethal side effects that provide a new challenge for oncologists, one addressed by proposed guidelines for systematically dealing with the toxicities of these drugs.
By reprogramming skin cells into nerve cells, researchers are creating cell models of the human brain. In a new study, the researchers describe how cells from patients with the severe developmental disease lissencephaly differ from healthy cells. The method can provide vital new knowledge on difficult-to-study congenital diseases.
A new lung cell type that is implicated in the body’s innate immune defense against the bacteria Streptococcus pneumoniae — one of the leading causes of pneumonia worldwide — has been discovered by researchers.
Scientists say a new study indicates that the excessive burst of new brain cells after a traumatic head injury that researchers have traditionally believed helped in recovery could instead lead to epileptic seizures and long-term cognitive decline.
New research suggests elementary school-age children who own cell phones may be particularly vulnerable to cyberbullying.
Researchers have demonstrated that hematopoietic stem cell (HSC) transplants can be improved by treatments that temporarily prevent the stem cells from dying. The approach could allow those in need of such transplants, including leukemia and lymphoma patients, to be treated with fewer donor stem cells while limiting potential adverse side effects.
The bacterial pathogen Legionella pneumophila has developed a specific strategy to target the host cell mitochondria, the organelles in charge of cellular bioenergetics, scientists have shown. New work provides precious information on how a pathogen manipulates the cellular metabolism to replicate intracellularly, and proposes a new concept of protection of host cells from Legionella-induced mitochondrial changes in order to fight infection.
Researchers have developed new methods to track cells in mice which could help to reduce animal experiments.
An unexpected role for a white blood cell called the Natural Killer (NK) cell — a critical cell for ridding the body of infection and cancer, has been discovered. The NK cell is a ‘vigilante’ killer — a white blood cell that destroys invaders and cancer cells through a process of ‘identity card’ checking. The researchers’ new work shows that violent vigilante NK cells act as helper cells to start up the immune response.
A type of mouse widely used to assess how the human immune system responds to transplanted stem cells does not reflect what is likely to occur in patients, according to a new study.