No magic pill to cure alcohol dependence yet


A new study has found no reliable evidence for using nalmefene, naltrexone, acamprosate, baclofen or topiramate to control drinking in patients with alcohol dependence or alcohol use disorder. At best, some treatments showed low to medium efficacy in reducing drinking, but those findings were from studies with a high risk of bias. None demonstrated any benefit on health outcomes.

Pay more, smoke less: Possible effects of raising tobacco taxes across the EU


Raising tobacco taxes to increase cigarette prices could reduce cigarette consumption and smoking-associated deaths (SADs) in all 28 EU countries, according to a new study. In higher income countries, raising tobacco taxes could increase revenues that could be spend on prevention and control programs, while in lower income countries tax revenues may be negatively affected, researchers suggest.

One e-cigarette with nicotine leads to adrenaline changes in nonsmokers' hearts


Electronic cigarettes have been touted as both a safer alternative for smokers and as an effective way for people to gradually quit smoking altogether. But a new study shows that nicotine inhaled from e-cigarettes can greatly increase a person’s heart rate and aggravate the sympathetic nervous system.

Discovery helps improve accuracy of CRISPR-Cas9 gene editing


A detailed study of how domains within the Cas9 protein move when the molecule binds to DNA has allowed scientists to locate the protein that monitors the fidelity of binding between the Cas9 single-guide RNA and its DNA target. The researchers then tweaked this domain to boost specificity, creating the highest fidelity Cas9 protein to date.